Aids Research Paper

Chronic immune activation and inflammation are considered major drivers of the disease, but it is unclear which interactions of HIV with the innate immune system via which receptors are critical.

Chronic immune activation and inflammation are considered major drivers of the disease, but it is unclear which interactions of HIV with the innate immune system via which receptors are critical.

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HIV/AIDS research includes all medical research that attempts to prevent, treat, or cure HIV/AIDS, as well as fundamental research about the nature of HIV as an infectious agent and AIDS as the disease caused by HIV.Such persons are of great interest to researchers, who feel that a study of their physiologies could provide a deeper understanding of the virus and disease.An HIV vaccine is a vaccine that would be given to a person who does not have HIV, in order to confer protection against subsequent exposures to HIV, thus reducing the likelihood that the person would become infected by HIV. Various HIV vaccines have been tested in clinical trials almost since the discovery of HIV.With unprecedented speed, antiretrovirals became available that target different steps in the HIV replication cycle, which are now effectively used in combination therapy.Combination antiretroviral therapy also reduces the likelihood of onward HIV transmission, and HIV treatment is a crucial component of HIV prevention, in combination with public health approaches, in particular the promotion of regular HIV testing and safe practices.The binding causes conformation changes and results in the membrane fusion between HIV and cell membrane.Active infection occurs in most cells, while latent infection occurs in much fewer cells 1, 2 and at very early stages of HIV infection.In the past decade, our thinking about HIV pathogenesis has significantly changed, and it is now believed that not the loss of CD4 T cells through HIV cytopathic infection, but the chronic inflammation that HIV induces, may eventually cause immune deficiency and non-AIDS diseases such as cardiovascular disease and inflammation induced artherosclerosis.However, the virus-host interactions that differ pathologically from non-pathological HIV and SIV are still unknown.Despite enormous international collaborative efforts and detailed research into neutralizing antibodies and HIV specific cellular immunity, effective immunotherapy or an efficacious vaccine are not yet available.Major aspects of HIV infection are still not well understood, and much remains to be done to ensure affected people and communities benefit from the knowledge that has accumulated and that drives clinical and public health innovation.